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As humans learned the techniques of agriculture, they abandoned their diffuse hunter-gatherer ways and established cities and governments. The resulting population density made humans ripe for infectious diseases like smallpox and malaria. Alleles that helped protect against disease proved useful and won out.

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The domestication of cattle for milk production also led to genetic change. Among people of northern European descent, lactose intolerance -- the inability to digest milk in adulthood -- is unusual today. But it was universal before a genetic mutation arose about 8,000 years ago that made lactose tolerance continue beyond childhood.

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A sudden change in the human genome, they suggest, made for more creative, inventive brains.

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