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Bisphenol A - Wikipedia, the free encyclopedia

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Bisphenol A, like many other compounds, is known to be an estrogen receptor agonist.

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It has been claimed that these effects lead to health problems such as, in men, lowered sperm count and infertile sperm. Recent studies have confirmed that bisphenol A exposure during development has carcinogenic effects and produce precursors of breast cancer.[11][12] Bisphenol A has been shown to have developmental toxicity, carcinogenic effects, and possible neurotoxicity.[13][14] Recent studies suggest it may also be linked to obesity by triggering fat-cell activity.[15] Schizophrenia research indicates endocrine disruptors like BPA may be involved in schizophrenia pathogenesis.[16]

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Bisphenol A has been known to leach from the plastic lining of canned foods and, to a lesser degree, polycarbonate plastics that are cleaned with harsh detergents or used to contain acidic or high-temperature liquids.[22] The chemical is found in almost everyone that lives in developed countries at low concentrations. Infants fed with liquid infant formula have among the highest exposures of anyone eating canned foods.

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The city of San Francisco, California, banned the sale of baby bottles and other products for young children containing bisphenol A effective December 2006, and was, at the time, the only jurisdiction in the world to outright forbid the substance.[25] The ban was never enforced, and in May 2007 the city repealed the ban. In January 2006

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As an environmental contaminant this compound interferes with nitrogen fixation at the roots of leguminous plants associated with the bacterial symbiont Sinorhizobium meliloti. Despite a half-life in the soil of only 1–10 days, its ubiquity makes it an important pollutant.[31]

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